APPLICATIONS

Biodistribution

VECTOR TRANSDUCTION EFFICENCY ASSAYED ACROSS ENTIRE ORGAN SYSTEMS

Whole Brain Analysis

Quickly quantify measures of vector transduction efficiency across entire organs with subcellular resolution.

 

Gene therapy has recently undergone a renaissance with the advent of specialized molecular biological techniques used to generate disease-specific reagents. Controlled tissue distribution and expression from gene transfer vectors is essential for the utility of a viable therapeutic for gene therapy.  As such, it's important to screen viral serotypes across a range of properties pertaining to antigenicity, in vivo tropism and receptor interactions, all of which can play a major role in determining the regional and cellular transduction efficiencies of viral vector strains across different mammalian organs.

Reveal the global and regional definition of the pattern of vector infection and expression throughout an organ. Recover tissue sections using the SlicePlacer, which can also undergo secondary analysis to characterize specific molecular signatures and targets. In addition to screening the primary organ of interest, it's possible to screen additional organs (liver, heart, spleen, etc.) from the same animal to quantify potential off-target effects.

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